百科全书派（法语：Encyclopédiste）是指18世纪法国一部分启蒙思想家于编纂《百科全书》（全称为《百科全书，或科学、艺术和工艺详解词典》）过程中以狄德罗为核心形成的一个学术团体。

《百科全书》主编为狄德罗，副编为让·勒朗·达朗贝尔。在编篡《百科全书》之前，狄德罗已经开始与一些志同道合的自由思想作家结成了一个学术圈子，主要人员有孟德斯鸠、魁奈、杜尔哥、伏尔泰、卢梭、布丰、孔迪亚克、达朗贝尔、马布利、霍尔巴赫、爱尔维修等不少法国启蒙运动时期之著名人物。这些人也都参与了《百科全书》的编辑。

The Encyclopédistes were a members of the Société des gens de lettres, a French writer's society, who contributed to the development of the Encyclopédie from June 1751 to December 1765 under editors Denis Diderot and Jean le Rond d'Alembert. The composition of the 17 volumes of text and 11 volumes of plates of the Encyclopédie was the work of over 150 authors belonging, in large part, to the intellectual group known as the philosophes. They promoted the advancement of science and secular thought and supported tolerance, rationality, and open-mindedness of the Enlightenment.