So in severe vWF deficiency, factor VIII gets broken down faster and can become deficient, too.

在vWF缺乏严重时，因子VIII会更快被分解，继而也出现缺乏。

Desmopressin stimulates vWF release from endothelial cells, which promotes the stabilization of the residual factor VIII.

去氨加压素刺激血管性血友病因子vWF从内皮细胞释放，这能增强剩余因子VIII的稳定性。

For hemophilia A, desmopressin, also called DDAVP (1-deamino-8-D-arginine vasopressin) is helpful for patients with mild, quantitative factor VIII deficiency.

对于血友病A，去氨加压素（DDAVP）有助于治疗轻症因子VIII数量缺乏。

The factor V degradation product also binds to this complex and further enhances its ability to cleave more active factor V and active factor VIII.

V因子的分解产物也结合到复合物上，进一步增强了裂解更多活跃的V因子和VIII因子的能力。

And you're missing one of the clotting factors, specifically Factor VIII.

而且您缺少一种凝血因子，特别是因子 VIII。

I don't know how he knows it's specifically Factor VIII, that's really impressive.

我不知道他是怎么知道它特别是因子 VIII 的，这真是令人印象深刻。

This increases circulating factor V and factor VIII levels, and " tips the scale" toward coagulation, putting them at increased risk for thrombosis, or developing blood clots.

这使得血液循环中V因子和VIII因子数量增多，更容易发生凝血，导致血栓形成的风险增加。

The key issue was that the supplies of Factor VIII that were contaminated had been imported from the United States.

关键问题是受污染的因子 VIII 供应品是从美国进口的。

By far the most common of these are deficiencies of factor VIII which gives rise to factor VIIIa and is stabilized by another factor called von Willebrand factor.

目前为止，大多数的血友病通常是因子VIII缺乏症；因子VIII能转变为因子VIIIa，并被血管性血友病因子（vWF）固定。

And what happened was I think there was originally a pledge that the UK would become self-sufficient in Factor VIII — that hadn't happened.

发生的事情是， 我认为最初有一个承诺， 即英国将在因子 VIII 中实现自给自足——但这并没有发生。

And suddenly here was evidence that you could go into hospital and have a regular blood transfusion or particularly be a haemophiliac looking to have a blood clotting agent called Factor VIII and you could end up contaminated with this disease.

突然间，有证据表明你可以去医院并定期输血， 或者特别是血友病患者想要使用一种叫做因子 VIII 的凝血剂， 你最终可能会感染这种疾病。