Ganaxolone

Ganaxolone (INN, also known as CCD-1042 and 3α-Hydroxy-3β-methyl-5α-pregnan-20-one) is a CNS-selective GABA_A modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABA_A receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone.

单词	Ganaxolone
释义	Ganaxolone 英语百科 Ganaxolone Ganaxolone (INN, also known as CCD-1042 and 3α-Hydroxy-3β-methyl-5α-pregnan-20-one) is a CNS-selective GABA_A modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6 Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABA_A receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone.
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