甘油-3-磷酸脱氢酶 (NAD+) Glycerol-3-phosphate dehydrogenase
（重定向自GPDH）
甘油-3-磷酸脱氢酶 (NAD)（英语：glycerol-3-phosphate dehydrogenase (NAD)，EC 1.1.1.8）是一种以NAD或NADP为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：
甘油-3-磷酸脱氢酶 (NAD)主要参与甘油磷酸脂的代谢过程。
GPDH
中文百科
英语百科
Glycerol-3-phosphate dehydrogenase 甘油-3-磷酸脱氢酶 (NAD+)
（重定向自GPDH）
![Fig. 1. Schematic overview of fermentative and oxidative glucose metabolism of Saccharomyces cerevisiae. (A) upper part of glycolysis, which includes two sugar phosphorylation reactions. (B) fructose-1,6-bisphosphate aldolase, splitting the C6-molecule into two triose phosphates (C) triosephosphate isomerase, interconverting DHAP and GAP. (D) glycerol pathway reducing DHAP to glycerol-3-phosphate (G3P) by G3P dehydrogenase, followed by dephosphorylation to glycerol by G3Pase. (E) The lower part of glycolysis converts GAP to pyruvate while generating 1 NADH and 2 ATP via a series of 5 enzymes. (F) Alcoholic fermentation; decarboxylation of pyruvate by pyruvate decarboxylase, followed by reduction of acetaldehyde to ethanol. (G) mitochondrial pyruvate-dehydrogenase converts pyruvate to acetyl-CoA, which enters the tricarboxylic acid cycle. (H) external mitochondrial NADH dehydrogenases. (I) mitochondrial G3P dehydrogenase. Electrons of these three dehydrogenases enter the respiratory chain at the level of the quinol pool (Q). (J) internal mitochondrial NADH dehydrogenase. (K) ATP synthase. (L) generalized scheme of NADH shuttle. (M) formate oxidation by formate dehydrogenase.[4]](/uploads/202501/16/Schematic_overview_of_fermentative_and_oxidative_glucose_metabolism_of_Saccharomyc4220.png)
Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate (aka glycerone phosphate, outdated) to sn-glycerol 3-phosphate.
Glycerol-3-phosphate dehydrogenase serves as a major link between carbohydrate metabolism and lipid metabolism. It is also a major contributor of electrons to the electron transport chain in the mitochondria.
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