Floctafenine

Flocatfenine synthesis: DE 1815467 ; eidem, U.S. Patent 3,644,368 Roussel Uclaf; [1]

Floctafenine is a non-steroidal anti-inflammatory drug (NSAID).

The scheme involves first the conversion of ortho-trifluoromethyl aniline (1) to a quinolol. The compound is thus condensed with EMME (Ethoxy Methylene Malonic Diethyl Ester) and cyclized thermally (2). That intermediate is then saponified; the resulting acid is decarboxylated and finally converted to the 4-chloroquinoline (3) by reaction with phosphorus oxychloride. The displacement of chlorine with methyl anthranilate (4) then affords the coupled intermediate (5). An ester interchange of that product with glycerol leads to the glyceryl ester. There is thus obtained the NSAID floctafenine.

单词	Idarac
释义	Idarac 英语百科 Floctafenine Floctafenine is a non-steroidal anti-inflammatory drug (NSAID). The scheme involves first the conversion of ortho-trifluoromethyl aniline (1) to a quinolol. The compound is thus condensed with EMME (Ethoxy Methylene Malonic Diethyl Ester) and cyclized thermally (2). That intermediate is then saponified; the resulting acid is decarboxylated and finally converted to the 4-chloroquinoline (3) by reaction with phosphorus oxychloride. The displacement of chlorine with methyl anthranilate (4) then affords the coupled intermediate (5). An ester interchange of that product with glycerol leads to the glyceryl ester. There is thus obtained the NSAID floctafenine.
随便看	Chromous chloride的意思 chromous choloide的意思 chromous compond的意思 chromous compound的意思 chromous cyanide的意思 Chromous fluoride的意思 chromous formate的意思 chromous fulfide的意思 chromous hydroxide的意思 chromous iodide的意思 chromous nitrate的意思 Chromous oxalate的意思 Chromous oxide的意思 chromous phosphate的意思 chromous salt的意思 chromous salts的意思 chromous selenide的意思 chromous sulfate的意思 chromous sulfide的意思 chromow的意思 chromowulfenite的意思 chromowulferite的意思 Chromoxane的意思 Chromoxane cyanine R的意思 chromoxylograph的意思

Idarac

Floctafenine