Although the exact mechanism is unknown, repeated firing of neurons causes changes in the synapse, which interferes with normal impulse conduction.

虽然确切的机制尚不清楚，神经元的反复放电会引起突触的变化，从而干扰正常的脉冲传导。

The result is a progressive loss of nerve impulse conduction, which causes loss of sensation and muscle paralysis in the limbs and can eventually lead to respiratory failure.

临床表现即进行性神经冲动传导丧失，引起四肢的知觉消失和肌麻痹，最终导致呼吸衰竭。

As this value becomes less negative in hyperkalemia, the number of available sodium channels DEcreases, resulting in a SLOWER influx of sodium and subsequently SLOWER impulse conduction.

在高钾血症中，随着这个值变为较小负值，可用钠通道数量减少，导致钠流入减慢，随后脉冲传导减慢。