反坦克地雷（Anti-tank mine，简称“AT mine”），是一种用于破坏或摧毁坦克和装甲运兵车等车辆的地雷。与反步兵地雷相比，反坦克地雷通常拥有更多的炸药，并引信被改造成只会被车辆触发。

现代的反坦克地雷更为先进，不再是简单依靠遥控器或车辆的压力引爆的铁盒子：

为了避免被发现，大多数现代反坦克地雷的雷体和外壳由塑料制成。它们组合使用压力或磁激活雷管来确保它们只被车辆引发。

An anti-tank mine, (abbreviated to "AT mine"), is a type of land mine designed to damage or destroy vehicles including tanks and armored fighting vehicles.

Compared to anti-personnel mines, anti-tank mines typically have a much larger explosive charge, and a fuze designed only to be triggered by vehicles or, in some cases, tampering with the mine.