Kafue National Park is the largest national park in Zambia, covering an area of about 22,400 km² (similar in size to Wales or Massachusetts). It is the second largest park in Africa and is home to over 55 different species of animals.

The park is named for the Kafue River. It stretches over three provinces: North Western, Central and Southern. The main access is via the Great West Road from Lusaka to Mongu which crosses the park north of its centre. Seasonal dirt roads also link from Kalomo and Namwala in the south and south-east, and Kasempa in the north.