核质（英语：Nucleoplasm）是真核细胞中细胞核内除核仁外，所含的其他部分物质。

维基共享资源中相关的多媒体资源：核质

Similar to the cytoplasm of a cell, the nucleus contains 'nucleoplasm' (nucleus sap) or karyoplasm. The nucleoplasm is one of the types of protoplasm, and it is enveloped by the nuclear membrane or nuclear envelope. The nucleoplasm includes the chromosomes and nucleoli. Many substances such as nucleotides (necessary for purposes such as the replication of DNA) and enzymes (which direct activities that take place in the nucleus) are dissolved in the nucleoplasm. The soluble, liquid portion of the nucleoplasm is called the nucleosol or nuclear hyaloplasm.