Klinefelter syndrome develops when a gamete, either sperm or egg, contains at least one extra X chromosome.

异常在配子时期就存在了，精子和卵子都有可能发生，异常的配子会多出至少一条X染色体。

There are also diseases that can cause osteoporosis like Turner syndrome, hyperprolactinemia, Klinefelter syndrome, Cushing syndrome, and diabetes mellitus.

也有一些疾病会导致骨质疏松，比如Turner综合征、高催乳素血症、先天性睾丸发育不全综合征、皮质醇增多症以及糖尿病。

Klinefelter syndrome is diagnosed with a karyotype which visualizes each chromosome including the X, Y, and extra X chromosomes.

核型分析可观察到患者的每条染色体，包括X、Y与额外的X染色体，可用来确诊Klinefelter综合征。

In Klinefelter syndrome, this hormone balance is altered; that extra x-chromosome interrupts the normal function of the sertoli and leydig cells.

在Klinefelter综合征患者体内，这些激素的平衡被改变了额外的X染色体，打乱了睾丸支持细胞和睾丸间质细胞的正常功能。

Blood tests after puberty can also indicate Klinefelter syndrome because there are low levels of testosterone and high levels of luteinizing and follicle stimulating hormones

青春期后的血液检查也可以辅助Klinefelter综合征的诊断，因为该病患者的血液睾酮水平会异常降低，血液LH和FSH水平会异常升高。

If failure also happens during meiosis in these germ cells as they give rise to gametes, other XXXXY, XXXY and XXYY genotypes that also lead to Klinefelter syndrome can result including the rare situation where there's an additional Y chromosome.

如果有丝分裂和减数分裂均发生了不分离，那么这类Klinefelter综合征患者的基因型就可能是XXXXY，XXXY和XXYY等，包括了同时多出一条Y染色体的罕见情况。

In Klinefelter syndrome, the sex chromosome pairs which is either XX or XY don't separate in meiosis I in the male or female germ cell and this resulted in two gametes with a pair of X chromosomes and two gametes without X chromosomes.

Klinefelter综合征中，配对的XX或XY性染色体对在父亲或母亲的第一次减数分裂中没有分离，从而产生了两个有两条X染色体的配子以及两个没有X染色体的配子。