Kotzebue/ˈkoʊtsʌˌbjuː/ (Qikiqtaġruk/qikiqtaʁʐuk/ in Iñupiaq) is a city in the borough seat of Northwest Arctic Borough in the U.S. state of Alaska. The population of the city was 3,201 as of the 2010 census. Kotzebue is the largest city in the Northwest Arctic Borough.