《大卫·莱特曼晚间秀》（英语：Late Show with David Letterman）是美国哥伦比亚广播公司（CBS）于周一到周五晚上十一点至午夜间播出的喜剧和脱口秀节目。节目于1993年8月30日首播，由大卫·莱特曼制作并主持。其音乐总监和CBS自有乐队的指挥是保罗·沙佛（Paul Shaffer）。本节目的录像棚位于纽约百老汇的Ed Sullivan 剧场。

据节目自身的2004年8月版的官方通讯称，十一年里大卫晚间秀共播出了2264场次，包括4082个嘉宾访谈，1382个特写，1668场音乐表演，473个嘉宾和客串音乐人参与CBS乐队演奏，275个现场喜剧和至少1382次游行。在大卫·莱特曼宣布退休后，2015年5月20日播出最后一集。原时段由史蒂芬·科拜尔接替，原节目改为《斯蒂芬·科尔伯特晚间秀》（Late Show with Stephen Colbert）。

Late Show with David Letterman is an American late-night talk show hosted by David Letterman on CBS, the first iteration of the Late Show franchise. The show debuted on August 30, 1993, and was produced by Letterman's production company, Worldwide Pants Incorporated and CBS Television Studios. The show's music director and leader of the house band, the CBS Orchestra, was Paul Shaffer. The head writer was Matt Roberts and the announcer was Alan Kalter. Of the major U.S. late-night programs, Late Show ranked second in cumulative average viewers over time and third in number of episodes over time. In most U.S. markets the show aired from 11:35 p.m. to 12:37 a.m. Eastern and Pacific Time, and recorded Monday through Wednesdays at 4:30 p.m., and Thursdays at 3:30 p.m. and 6:00 p.m. Eastern Time. The second Thursday episode usually aired on Friday of that week.