If hypoxia lasts too long, intracellular edema can lead to cell membrane rupture, causing proteins to leak out into the extracellular space.
如果缺氧时间过长，细胞内水肿会造成细胞膜破裂，导致蛋白质外漏到细胞外。
英语百科
Rupture of membranes
Rupture of membranes (ROM) or amniorrhexis is a term used during pregnancy to describe a rupture of the amniotic sac. Normally, it occurs spontaneously at full term either during or at the beginning of labor. Rupture of the membranes is known colloquially as "breaking the water" or as one's "water breaking." A premature rupture of membranes (PROM) is a rupture of the amnion that occurs prior to the onset of labor.