MKUltra计划（英语：Project MKUltra），是指由美国中央情报局统筹的一项人类思想控制（英语：Mind control）试验计划。该计划始于20世纪50年代初，至1953年被正式认可，1964年缩减规模，1967年进一步削减，并在1973年正式停止。主要研究人类大脑的潜能控制，使用生物制剂还有药物观察对人脑的影响，军方目的是制定一个大脑控制系统，可对重点目标进行斩首。计划涉及许多非法活动，特别是以不知情的美国和加拿大公民作实验对象，引起有关合法性的争议。

在美国国会丘奇委员会的揭发下，MKUltra计划在1975年首次引起大众关注。总统福特因而指示美国总统调查中情局美国境内活动委员会调查此事，惟计划的官方文档早已于1973年被当时的中央情报总监下令销毁，调查方向只得转移到受试者身上或从小量的民间纪录中寻找蛛丝马迹。

Project MKUltra—sometimes referred to as the CIA's mind control program—was the code name given to an illegal program of experiments on human subjects, designed and undertaken by the United States Central Intelligence Agency (CIA). Experiments on humans were intended to identify and develop drugs and procedures to be used in interrogations and torture, in order to weaken the individual to force confessions through mind control. Organized through the Scientific Intelligence Division of the CIA, the project coordinated with the Special Operations Division of the U.S. Army's Chemical Corps. The program began in the early 1950s, was officially sanctioned in 1953, was reduced in scope in 1964, further curtailed in 1967 and officially halted in 1973. The program engaged in many illegal activities, including the use of unwitting U.S. and Canadian citizens as its test subjects, which led to controversy regarding its legitimacy. MKUltra used numerous methodologies to manipulate people's mental states and alter brain functions, including the surreptitious administration of drugs (especially LSD) and other chemicals, hypnosis, sensory deprivation, isolation, verbal and sexual abuse, as well as various forms of torture.