纽斯河（英语：Neuse River）美国北卡罗来纳州的一条河流，长约275英里（443公里），是北卡罗来纳州境内所有不跨州的河流中最长的一条。

The Neuse River is a river rising in the Piedmont of North Carolina and emptying into Pamlico Sound below New Bern. Its total length is approximately 275 miles (443 km), making it the longest river entirely contained in North Carolina. The Trent River joins the Neuse at New Bern. Its drainage basin, measuring 5,630 square miles (14,600 km) in area, also lies entirely inside North Carolina. It is formed by the confluence of the Flat and Eno rivers prior to entering the manmade, artificial Falls Lake reservoir in northern Wake County. Its fall line shoals, known as the Falls of the Neuse, lie submerged under the waters of Falls Lake.