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单词 NOESY
释义

NOESY

中文百科

关联性磁振频谱 Two-dimensional nuclear magnetic resonance spectroscopy

(重定向自NOESY)
1H COSY spectrum of 孕酮
在COSY NMR实验,样品的共振信号是在时间间隔t2时读取,之前有两个射频脉冲p1与p2,此二脉冲间隔时间t1是可调整的。
蛋白质NleG3-2的某个碎片的1H–15N HSQC谱,每个峰交叉峰意味着一个键合的氮氢键,横纵坐标对应于所键合的氮氢的化学位移;一些峰标出了所给出这个信号的氨基酸组分。[2]

关联性磁振频谱Correlation spectroscopy, COSY)是二维核磁共振(NMR)频谱学中的一种技术,其他二维NMR技术包括有J频谱(J-spectroscopy)、交换谱Exchange spectroscopy, EXSY)及核欧佛豪瑟效应频谱(Nuclear Overhauser effect spectroscopy, NOESY)。二维NMR频谱对于分子提供了比一维NMR频谱更多的信息,在对分子结构的决定上极为有用,尤其当分子极为复杂,难以用一维NMR来研究之时。历史上第一项二维NMR实验方法——COSY是由Jean Jeener于1971年首先提出,其为布鲁塞尔自由大学(Université Libre de Bruxelles)教授。真正的实验由Walter P. Aue、Enrico Bartholdi 及理乍得·恩斯特(Richard R. Ernst)三人首先完成,于1976年发表。

英语百科

Two-dimensional nuclear magnetic resonance spectroscopy 关联性磁振频谱

(重定向自NOESY)
In standard COSY, the preparation (p1) and mixing (p2) periods each consist of a single 90° pulse separated by the evolution time t1, and the resonance signal from the sample is read during the detection period over a range of times t2.
1H COSY spectrum of progesterone
1H–15N HSQC spectrum of a fragment of the protein NleG3-2.  Each peak in the spectrum represents a bonded N-H pair, with its two coordinates corresponding to the chemical shifts of each of the H and N atoms.  Some of the peaks are labeled with the amino acid residue that gives that signal.[13]

Two-dimensional nuclear magnetic resonance spectroscopy (2D NMR) is a set of nuclear magnetic resonance spectroscopy (NMR) methods which give data plotted in a space defined by two frequency axes rather than one. Types of 2D NMR include correlation spectroscopy (COSY), J-spectroscopy, exchange spectroscopy (EXSY), and nuclear Overhauser effect spectroscopy (NOESY). Two-dimensional NMR spectra provide more information about a molecule than one-dimensional NMR spectra and are especially useful in determining the structure of a molecule, particularly for molecules that are too complicated to work with using one-dimensional NMR.

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更新时间:2025/6/19 10:26:58