Nuclear dots

Nuclear dots (also known as Nuclear bodies, nuclear domains, or PML bodies) are punctate structures found in the nuclei of certain cells. Nuclear bodies (NBs) were first seen as prominent interchromatin structures in the nuclei of malignant or hyperstimulated animal cells identified using anti-sp100 autoantibodies from primary biliary cirrhosis and subsequently the promyelocytic leukemia (PML) factor, but appear also to be elevated in many autoimmune and cancerous diseases. Nuclear dots are metabolically stable and resistant to nuclease digestion and salt extraction.

单词	Nuclear bodies
释义	Nuclear bodies 英语百科 Nuclear dots Nuclear dots (also known as Nuclear bodies, nuclear domains, or PML bodies) are punctate structures found in the nuclei of certain cells. Nuclear bodies (NBs) were first seen as prominent interchromatin structures in the nuclei of malignant or hyperstimulated animal cells identified using anti-sp100 autoantibodies from primary biliary cirrhosis and subsequently the promyelocytic leukemia (PML) factor, but appear also to be elevated in many autoimmune and cancerous diseases. Nuclear dots are metabolically stable and resistant to nuclease digestion and salt extraction.
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