氧气毒性指吸入高压氧气的时候的中毒状态，也称为氧气毒性症，氧气中毒。这种症状历史上曾称以发现他们的19世纪研究员命名，称为保罗伯特症和劳伦史密斯症。

严重的症状可导致死亡，多数症状表现在中枢神经系统、肺和眼睛。氧气毒性可能对潜水员和进行高压氧疗的人造成威胁。深水潜水员使用高达100%浓度的氧气，他们在使用这些氧气前必须接受特殊的培训。近年来氧气已在一些国家作为休闲药品出售。美国药监局发出警告要求心脏和肺部等疾病的人群避免使用氧气。

Oxygen toxicity is a condition resulting from the harmful effects of breathing molecular oxygen (O
2) at increased partial pressures. It is also known as oxygen toxicity syndrome, oxygen intoxication, and oxygen poisoning. Historically, the central nervous system condition was called the Paul Bert effect, and the pulmonary condition the Lorrain Smith effect, after the researchers who pioneered its discovery and description in the late 19th century. Severe cases can result in cell damage and death, with effects most often seen in the central nervous system, lungs and eyes. Oxygen toxicity is a concern for underwater divers, those on high concentrations of supplemental oxygen (particularly premature babies), and those undergoing hyperbaric oxygen therapy.