Phyllobates is a genus of poison dart frogs native to Central and South America, from Nicaragua to Colombia.

Phyllobates contains the most poisonous species of frog, the golden poison frog (Phyllobates terribilis). They are typical of the poison dart frogs, in that all species are colourful, and have varying degrees of toxicity. Only species of Phyllobates are used by natives of South American tribes as sources of poison for their hunting darts. The most toxic of the many poisonous alkaloids these frogs emit from their skins is batrachotoxin, but a wide number of other toxic compounds are secreted by these frogs.