皮斯卡特奎斯县（英语：Piscataquis County）是美国缅因州中部偏西的一个县，面积11,337平方公里。根据2010年人口普查，本县共有人口17,235人，是缅因州人口最少的县份。本县县治为多佛法斯克罗镇（Dover-Foxcroft）。

皮斯卡特奎斯县于1838年3月23日成立，系自佩诺布斯科特县和萨默塞特县独立。本县县名来自阿布纳基人语言，意思是「水流湍急」。本县位于缅因州的地理中心。起初，本县领土延伸至美加边境，但接壤加拿大的一片土地于1844年被割予阿鲁斯图克县。尽管如此，本县仍然是密西西比河以东其中一个面积最大的县份。

Piscataquis County is a county located in the U.S. state of Maine. As of the 2010 census, its population was 17,535, making it Maine's least-populous county. Its county seat is Dover-Foxcroft. The county was incorporated on 23 March 1838, taken from the western part of Penobscot County and the eastern part of Somerset County, and is named for an Abenaki word meaning "branch of the river" or "at the river branch."