Poggio Rusco is a small town and comune in the Province of Mantua, whose inhabitants number 6,641 as of January 1, 2015. It is 42 kilometres (26 mi) from the provincial capital.

The town extends its territory in the south-eastern Oltrepò Mantovano, 9 kilometres (6 mi) from the Po River and just 2 kilometres (1 mi) from Province of Modena, equidistant position to important cities of Po Valley like Mantua, Verona, Ferrara, Bologna and Modena.