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单词 Prins reaction
释义

Prins reaction

中文百科

普林斯反应

Prins反应(Prins reaction)

醛或酮与烯烃或炔烃在酸催化下的缩合反应。

此反应可用于制取二恶烷(与过量甲醛、低温)、1,3-二醇(与甲醛、水和质子酸)、烯丙醇(无水情况下失水)、氯代醇(与氯离子)和酯(与乙酸)等化合物。其中关键性的中间体是质子化的羰基化合物对烯烃的亲电加成所生成的碳正离子中间体。

英语百科

Prins reaction 普林斯反应

The Prins reaction is an organic reaction consisting of an electrophilic addition of an aldehyde or ketone to an alkene or alkyne followed by capture of a nucleophile. The outcome of the reaction depends on reaction conditions (scheme 1). With water and a protic acid such as sulfuric acid as the reaction medium and formaldehyde the reaction product is a 1,3-diol. When water is absent, the cationic intermediate loses a proton to give an allylic alcohol. With an excess of formaldehyde and a low reaction temperature the reaction product is a dioxane. When water is replaced by acetic acid the corresponding esters are formed.

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更新时间:2025/6/20 21:12:22