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单词 Protein design
释义

Protein design

原声例句
科学大揭秘

Collagen is a very stable protein designed to give support and structure to tissues like bone.

胶原蛋白是一种非常稳定的蛋白质,旨在为骨骼等组织提供支撑和结构。

经济学人-科技

Tooth enamel is made mostly of calcium phosphate, and genes that code for proteins designed to bind to calcium were particularly busy.

牙釉质主要是由磷酸钙构成的,因此编码与钙结合蛋白质的基因特别忙碌。

TED演讲(音频版) 2019年6月合集

Instead, with computational protein design, we can design new proteins to address these challenges today.

相反,通过计算蛋白质设计,我们可以设计新的蛋白质来应对当今的这些挑战。

TED演讲(音频版) 2019年6月合集

These advances are the beginning of the protein design revolution.

这些进步是蛋白质设计革命的开始。

TED演讲(音频版) 2019年6月合集

Making the world a better place through protein design is my life's work.

通过蛋白质设计让世界变得更美好是我一生的工作。

TED演讲(音频版) 2019年6月合集

Our goal is to build the Bell Laboratories of protein design.

我们的目标是建立蛋白质设计的贝尔实验室。

TED演讲(音频版) 2019年6月合集

Our audacious idea is to bring biology out of the Stone Age through technological revolution in protein design.

我们大胆的想法是通过蛋白质设计的技术革命将生物学带出石器时代。

精选英语短文

It could boost synthetic biology, by speeding up the creation of human-designed proteins designed to catalyse chemical reactions.

它可以通过加速创造旨在催化化学反应的人类设计蛋白质来促进合成生物学。

TED演讲(音频版) 2019年6月合集

And it's this unimaginably large space we can now explore using computational protein design.

我们现在可以使用计算蛋白质设计来探索这个难以想象的大空间。

TED演讲(音频版) 2019年6月合集

We are seeking to attract talented scientists from around the world to accelerate the protein design revolution, and we'll be focusing on five grand challenges.

我们正在寻求吸引来自世界各地的才华横溢的科学家来加速蛋白质设计革命,我们将专注于五个重大挑战。

Life Noggin

If the body comes into contact with the allergen again, these antibodies—which are proteins designed to attach to foreign substances and remove them from your body—will start a reaction to fight against it.

如果身体再次接触到过敏原, 这些抗体— — 它们是一种蛋白质,旨在附着在异物上并将它们从你的身体中清除— —会开始反应来对抗它。

经济学人 Science and technology

Rosetta, now called Rosetta Commons, has subsequently become a software package used by protein chemists around the world, and computational protein design has assisted in everything from vaccine development to the detection of toxic chemicals.

Rosetta, 现在称为Rosetta Commons,后来成为世界各地蛋白质化学家使用的软件包,计算蛋白质设计已为从疫苗开发到有毒化学物质检测等各个领域提供帮助。

英语百科

Protein design

The Top7 protein was one of the first proteins designed for a fold that had never been seen before in nature[5]
FSD-1 (shown in blue, PDB id: 1FSV) was the first de novo computational design of a full protein.[2] The target fold was that of the zinc finger in residues 33–60 of the structure of protein Zif268 (shown in red, PDB id: 1ZAA). The designed sequence had very little sequence identity with any known protein sequence.
Common protein design programs use rotamer libraries to simplify the conformational space of protein side chains. This animation loops through all the rotamers of the isoleucine amino acid based on the Penultimate Rotamer Library.[9]
Comparison of various potential energy functions. The most accurate energy are those that use quantum mechanical calculations, but these are too slow for protein design. On the other extreme, heuristic energy functions, are based on statistical terms and are very fast. In the middle are molecular mechanics energy functions that are physically-based but are not as computationally expensive as quantum mechanical simulations.[14]

Protein design is the rational design of new protein molecules to fold to a target protein structure, with the ultimate goal of designing novel function and/or behavior. Proteins can be designed from scratch (de novo design) or by making calculated variations on a known protein structure and its sequence (known as protein redesign). Rational protein design approaches make protein-sequence predictions that will fold to specific structures. These predicted sequences can then be validated experimentally through methods such as peptide synthesis, site-directed mutagenesis, or artificial gene synthesis.

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更新时间:2025/6/24 4:07:12