普尔喀丽亚（Aelia Pulcheria，399年1月19日－453年11月11日），东罗马皇后，阿卡狄奥斯与欧多克西亚之女，狄奥多西二世之姊。

普尔喀丽亚长狄奥多西二岁。414年元老院授予她奥古斯塔（Augusta），为狄奥多西二世摄政，以取代阿卡狄奥斯408年去世后当政的东罗马近卫军长官安提米乌斯。

为避免被迫成婚，普尔喀丽亚发愿终身受贞。她利用其弟性格的懦弱而取得了实质的权力。在教会的纷争中，她支持正统教会反对一性论派，谴责聂斯脱里。她421年包办狄奥多西成婚，娶雅典诡辩家的女儿，亦名欧多克西亚。433年欧多克西亚被放逐后，普尔喀丽亚的影响力迅速下降。其时皇帝被宦官克里沙斐乌（Chrysaphius）所狭，谣言指责她奸淫，被逐出宫廷。

St. Aelia Pulcheria /ˈiːliə pʌlˈkɪriə/ (19 January 398 or 399 – July 453) was the second child of Eastern Roman Emperor Arcadius and Empress Aelia Eudoxia. Her older sister was Flaccilla, born in 397 but assumed to have died young. Her younger siblings were Arcadia, born in 400; Theodosius II, the future emperor, born in 401; and Marina, also born in 401. When her father died in 408, her brother became Emperor Theodosius II at 7 years of age. On 4 July 414 at 15 years of age, Pulcheria proclaimed herself regent over him, then 13 years of age, and made herself "Augusta Imperatrix" and Empress of the Eastern Roman Empire. According to the historian Sozomen, in his Ecclesiastical History, Pulcheria made a vow of virginity when she became Augusta Imperatrix, and her sisters followed her example. Theodosius II died on 26 July 450, and thereafter Pulcheria married Marcian on 25 November 450, while simultaneously not violating her vow of virginity. Marcian and Pulcheria were proclaimed Emperor and Empress of the Eastern Roman Empire. Three years later, in July 453, Pulcheria died. The Roman Catholic Church and the Eastern Orthodox Church subsequently recognized her as a saint.