Sambuca Pistoiese is a town and comune of the province of Pistoia in the Italian region of Tuscany.
The comune is in fact constituted by several different villages (frazioni), the most important of which are Pàvana at 491 metres (1,611ft) and Treppio at 610 to 750 metres (2,000 to 2,460ft), along the valley of the two Limentras rivers.