圣克鲁兹作业（英语：Santa Cruz Operation，缩写为SCO），美国软件公司，位于美国加州圣克鲁兹。创立于1979年，它主要业务在于销售运行在Intel x86架构上的UNIX软件与提供顾问，著名产品有Xenix、SCO UNIX（稍后改名为SCO OpenServer）、与UnixWare。埃里克·雷蒙在《Unix编程艺术》一书中，称其为「第一间UNIX公司」。

2001年，将其SCO商标，与其旗下的UNIX产品及业务，出售给Caldera Systems，剩下的部份改名为塔兰泰拉公司（Tarantella, Inc.）。Caldera之后改名为SCO Group。

Santa Cruz Operation (SCO) was a software company based in Santa Cruz, California which was best known for selling three Unix variants for Intel x86 processors: Xenix, SCO UNIX (later known as SCO OpenServer), and UnixWare. Eric Raymond, in his book The Art of Unix Programming, calls SCO the "first Unix company". Prior to this, some prominent Unix vendors had been computer hardware manufacturers and telephone companies.