丝氨酸蛋白酶抑制剂 Serpin

（重定向自Serpinopathy）

A protease (grey) bound to a serpin reactive centre loop (RCL, blue). When the protease's catalytic triad (red) cleaves the RCL, it becomes trapped in an inactive conformation. (PDB: 1K9O)

The native state of serpins is an equilibrium between a fully stressed state (left) and a partially relaxed state (right). The five-stranded A-sheet (light blue) contains two functionally important regions for the serpin's mechanism, the breach and the shutter. The reactive centre loop (RCL, blue) exists in a dynamic equilibrium between the fully exposed conformation (left) and a conformation where it is partially inserted into the breach of the A-sheet (right).(PDB: 1QLP, 1YXA)[42][43]

The inhibitory mechanism of serpins involves a large conformational change (S to R transition). The serpin (white) first binds a protease (grey) with the exposed reactive centre loop (blue). When this loop is cleaved by the protease, it rapidly inserts into the A-sheet (light blue), deforming and inhibiting the protease. (PDB: 1K9O, 1EZX)Serine and cysteine proteases operate by a two-step catalytic mechanism. First, the substrate (blue) is attacked by the cysteine or serine of the catalytic triad (red) to form an acyl-enzyme intermediate. For typical substrates, the intermediate is resolved by hydrolysis by water. However, when the reactive centre loop (RCL) of a serpin is attacked, the conformational change (blue arrow) pulls the catalytic triad out of position, preventing it from completing catalysis. (Based on PDB: 1K9O, 1EZX)

丝氨酸蛋白酶抑制剂（英语：serpin）是具有相似结构蛋白质的蛋白质超家族，它是由于蛋白酶抑制活性被识别的，和在生命的各个界被发现的第一个蛋白质超家族。英文缩写丝氨酸蛋白酶抑制剂（英语：serpin）最初被创造，是因为第一个丝氨酸蛋白酶抑制剂对胰凝乳蛋白酶样丝氨酸蛋白酶（丝氨酸蛋白酶抑制剂）将要被识别的行为。

单词	Serpinopathy
释义	Serpinopathy 中文百科丝氨酸蛋白酶抑制剂 Serpin （重定向自Serpinopathy）丝氨酸蛋白酶抑制剂（英语：serpin）是具有相似结构蛋白质的蛋白质超家族，它是由于蛋白酶抑制活性被识别的，和在生命的各个界被发现的第一个蛋白质超家族。英文缩写丝氨酸蛋白酶抑制剂（英语：serpin）最初被创造，是因为第一个丝氨酸蛋白酶抑制剂对胰凝乳蛋白酶样丝氨酸蛋白酶（丝氨酸蛋白酶抑制剂）将要被识别的行为。
随便看	fabricated shapes的意思 fabricated ship的意思 fabricated steel的意思 fabricated steel body的意思 fabricated steel building的意思 fabricated stem的意思 fabricated stern frame的意思 fabricated structure的意思 fabricated textile的意思 fabricated type press的意思 fabricated universal steel members的意思 fabricated vessel的意思 fabricated window press的意思 fabricated wound的意思 fabricate history的意思 fabricate production costs的意思 fabric的意思 fabric的意思 fabricating cost的意思 fabricating dispatch的意思 fabricating factory的意思 fabricating news的意思 fabricating of facts的意思 fabricating plant的意思 fabricating process的意思