Base excision repair

8-oxoguanine forms a Hoogsteen base pair with adenine

Uracil DNA glycosylase flips a uracil residue out of the duplex, shown in yellow.

In biochemistry and genetics, base excision repair (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle. It is responsible primarily for removing small, non-helix-distorting base lesions from the genome. The related nucleotide excision repair pathway repairs bulky helix-distorting lesions. BER is important for removing damaged bases that could otherwise cause mutations by mispairing or lead to breaks in DNA during replication. BER is initiated by DNA glycosylases, which recognize and remove specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed by either short-patch (where a single nucleotide is replaced) or long-patch BER (where 2-10 new nucleotides are synthesized).

单词	Base excision repair
释义	Base excision repair 英语百科 Base excision repair In biochemistry and genetics, base excision repair (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle. It is responsible primarily for removing small, non-helix-distorting base lesions from the genome. The related nucleotide excision repair pathway repairs bulky helix-distorting lesions. BER is important for removing damaged bases that could otherwise cause mutations by mispairing or lead to breaks in DNA during replication. BER is initiated by DNA glycosylases, which recognize and remove specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed by either short-patch (where a single nucleotide is replaced) or long-patch BER (where 2-10 new nucleotides are synthesized).
随便看	controlled atmosphere arc welding的意思 controlled atmosphere furnace的意思 controlled atmosphere heat treatment的意思 controlled atmosphere kiln的意思 controlled atmosphere packaging的意思 controlled atmosphere spectrochemical analysis的意思 controlled atmosphere storage的意思 controlled atmospheric storage的意思 controlled attachment module的意思 controlled attenuator timer的意思 controlled attitude satellite的意思 controlled attribute的意思 controlled availability fertilizer的意思 controlled avalance rectifier的意思 controlled avalanche device的意思 controlled avalanche diode的意思 controlled avalanche rectifier的意思 controlled avalanche rectifier diode的意思 controlled avalanche silicon rectifier的意思 controlled avalanche transit time triode的意思 controlled avalence device的意思 controlled back pressure的意思 controlled barometer height的意思 controlled base region的意思 controlled bevel的意思