5-羟色胺和去甲肾上腺素再摄取抑制剂（英语：Serotonin–norepinephrine reuptake inhibitors） (SNRIs),是一种用来治疗重度抑郁症和其他精神障碍的抗抑郁药。SNRI有时候也用来治疗焦虑症，强迫症，多动症，慢性神经性疼痛，纤维肌痛综合征和缓解更年期症状。

SNRI是高效的5-羟色胺和去甲肾上腺素再摄取抑制剂。已知这些神经递质在控制情绪时发挥着重要的作用。 SNRI比使用更广泛但只能单独作用于5-羟色胺的选择性5-羟色胺再摄取抑制剂（SSRI）作用更多。

5-HT: 5-羟色胺- NE: 去甲肾上腺素- D: 多巴胺- NA: 不可用

Serotonin–norepinephrine reuptake inhibitors (SNRIs), also known as serotonin–noradrenaline reuptake inhibitors, are a class of antidepressant drugs used in the treatment of major depressive disorder (MDD) and other mood disorders. They are sometimes also used to treat anxiety disorders, obsessive-compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), chronic neuropathic pain, and fibromyalgia syndrome (FMS), and for the relief of menopausal symptoms.