南圣弗朗西斯科（葡萄牙语：São Francisco do Sul）是巴西圣卡塔琳娜州的一个市镇。总面积493平方公里，总人口37613人，人口密度76.3人/平方公里。

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São Francisco do Sul is a municipality in the Brazilian state of Santa Catarina. It covers an area of 540 km² (208 miles) and had an estimated population of 42,569 in 2011. It was founded as a village by the Portuguese in 1658. Despite the date of its foundation, there's a previous record that a famous navigator left Honfleur, Normandy in France by the year of 1503 and arrived at São Francisco do Sul, at the Bay of Babitonga, Jean Binot Paulmier De Gonneville is also recognised by many historians as one of the first, if not the first person to step and discover Sao Francisco's city. It is situated on the northern end of the Island of São Francisco at the entrance to the Babitonga Bay.