Usually, tau proteins support tiny tubes inside our axons called microtubules.

通常，tau蛋白要支撑称为微管即存在于轴突中的小管。

Spinal fluid from African-Americans contained lower levels of tau protein.

非裔美国人的脊髓液中tau蛋白含量较低。

TIA MCNEILL: It explains a lot because I am seeing a lot of that -- the tau protein.

提亚;这样就能说得通了，因为我看过很多像这样的tau蛋白质。

It's thought that repeated subconcussive hits damage the microtubules, causing the tau proteins to dislodge and clump together.

我们认为重复性震荡撞击会损伤微管，致使tau蛋白聚成一起。

There they make healthy Tau proteins start to misfold as well, spreading pathology across the brain.

在那里， 它们使健康的 Tau 蛋白也开始错误折叠，从而在整个大脑中传播病理学。

The second major target of future therapies is Tau protein, the main component of tangles.

未来治疗的第二个主要目标是Tau蛋白，它是缠结的主要成分。

Another problem seen in animal models is that misfolded Tau proteins can spread, across synapses, into healthy neurons.

在动物模型中发现的另一个问题是错误折叠的 Tau 蛋白可以通过突触扩散到健康的神经元中。

In a healthy brain, the Tau protein helps to lengthen and support microtubule structure.

在健康的大脑中，Tau蛋白有助于延长和支持微管结构。

Once the tau proteins start clumping together, they cause more clumps to form and continue to spread throughout the brain, even after head impacts have stopped.

一旦tau蛋白开始聚集成簇，将会引起更多簇的形成，并且延伸致整个大脑，即使头部影响已经停止。

Just like with beta-amyloid, antibodies capable of binding and clearing pathological Tau proteins are currently being developed and tested.

就像β淀粉样蛋白一样，抗体能够结合和清除病理性Tau蛋白目前正在开发和测试中。

Alvaro Pascual-Leone is a neurologist -- a brain scientist. He was one of the researchers who discovered the effect of brain injuries on the " tau" protein.

阿尔瓦罗·帕斯夸尔利昂是一位神经学家，也就是脑科学家，他是发现脑损伤对tau蛋白质影响的研究者之一。

Although current blood tests can accurately detect abnormalities in amyloid and tau proteins, detecting markers of nerve cell damage that are specific to the brain has been harder.

尽管目前的血液检测可以准确检测淀粉样蛋白和 tau 蛋白的异常，但检测大脑特有的神经细胞损伤的标志物一直比较困难。

Karikari and his colleagues around the world focused on developing an antibody-based blood test that would detect a particular form of tau protein called brain-derived tau, which is specific to Alzheimer's disease.

卡里卡里和他在世界各地的同事致力于开发一种基于抗体的血液测试，该测试将检测一种特殊形式的 Tau 蛋白，被称为脑源性 Tau 蛋白。这种蛋白是阿尔茨海默病患者特有的。

Current guidelines recommend detection of three distinct markers: abnormal accumulations of amyloid and tau proteins, as well as neurodegeneration – the slow and progressive loss of neuronal cells in specified regions of the brain.

目前的医学指南建议检测三种不同的标志物：淀粉样蛋白、Tau 蛋白的异常积累，以及神经变性（大脑特定区域神经元细胞的缓慢和渐进性丧失）。

Lastly, at (3) we have Tau hypothesis, which proposes that Alzheimer's may result from abnormal aggregation of Tau proteins that leads to the formation of tangles within nerve cells in the brain.

最后，在第（3）节，我们提出了Tau假说，认为阿尔茨海默病可能是由Tau蛋白的异常聚集，导致大脑神经细胞内形成缠结。