Thymidine phosphorylase

Arg-171, Ser-186, and Lys-190 interactions with thymine in ligand site of thymidine phosphorylase

In enzymology, a thymidine phosphorylase (EC2.4.2.4) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are thymidine and phosphate, whereas its two products are thymine and 2-deoxy-alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is thymidine:phosphate deoxy-alpha-D-ribosyltransferase. Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. This enzyme is involved in metabolic pathways: purine metabolism/pyrimidine metabolism, bladder cancer, and in the diagnosis of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

单词	Thymidine phosphorylase
释义	Thymidine phosphorylase 英语百科 Thymidine phosphorylase In enzymology, a thymidine phosphorylase (EC2.4.2.4) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are thymidine and phosphate, whereas its two products are thymine and 2-deoxy-alpha-D-ribose 1-phosphate. This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is thymidine:phosphate deoxy-alpha-D-ribosyltransferase. Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. This enzyme is involved in metabolic pathways: purine metabolism/pyrimidine metabolism, bladder cancer, and in the diagnosis of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
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