圣安尼奥雷阿尔城（葡萄牙语：Vila Real de Santo António）是葡萄牙法鲁区的一座城市，位于瓜迪亚纳河畔，邻近西班牙边境。

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Vila Real de Santo António (Portuguese pronunciation: [ˈvilɐ ʁiˈaɫ ðɨ ˈsɐ̃tu ɐ̃ˈtɔniu], often run together as [ˈvilɐ ʁiˈaɫ dɨ sɐ̃tɐ̃ˈtɔnju]) is a city, civil parish, and municipality in the Algarve, Portugal. The population in 2011 was 19,156, in an area of 61.25 km². It is one of the few municipalities in Portugal without territorial continuity: its territory comprehends two parts, with the municipal seat located in the eastern part. Both the city and the municipality are the southeasternmost of Portugal. Vila Real de Santo António was founded after the 1755 Lisbon earthquake, and largely expanded in 1774 using the same architectural and construction techniques employed in the reconstruction of Lisbon after the disaster.