Williamson ether synthesis

Ether synthesis by reaction of salicylaldehyde with chloroacetic acid and sodium hydroxide[1]

The Williamson ether synthesis is an organic reaction, forming an ether from an organohalide and an a deprotonated alcohol (alkoxide). This reaction was developed by Alexander Williamson in 1850. Typically it involves the reaction of an alkoxide ion with a primary alkyl halide via an S_N2 reaction. This reaction is important in the history of organic chemistry because it helped prove the structure of ethers.

单词	Williamson synthesis
释义	Williamson synthesis 英语百科 Williamson ether synthesis The Williamson ether synthesis is an organic reaction, forming an ether from an organohalide and an a deprotonated alcohol (alkoxide). This reaction was developed by Alexander Williamson in 1850. Typically it involves the reaction of an alkoxide ion with a primary alkyl halide via an S_N2 reaction. This reaction is important in the history of organic chemistry because it helped prove the structure of ethers.
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Williamson synthesis

Williamson ether synthesis