Body surface area

In physiology and medicine, the body surface area (BSA) is the measured or calculated surface area of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index, such as chemotherapy. Typically there is a 4–10 fold variation in drug clearance between individuals due to differing the activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and even more perniciously to underdosing (and increased risk of disease recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Estimation of BSA is simpler than many measures of volume.

单词	Body surface area
释义	Body surface area 原声例句 Osmosis-泌尿 In a normal healthy person, this is somewhere around 100-120 milliliter of fluid filtered per minute per 1.73 m2 of body surface area. 正常人的肾小球滤过率约为100-120ml/min/1.73m2；1.73 m2是体表面积平均值。 6 Minute English 六分钟英语 The head accounts for about 7% of the body surface area and the heat loss is fairly proportional to the amount of skin that's showing. 头占身体表面积的 7%，而热量散失跟露在外面的皮肤量是成比例的。 6 Minute English 六分钟英语 According to this view, heat loss - meaning the total amount of heat transferred away from something through its surface, is proportional to body surface area. 根据这个观点，热量散失 —— 指的是某物通过其表面所传送出去的热量的总量，跟身体的表面积成比例。 Asap SCIENCE 精选 Increasing temperatures may also affect our size; taller and thinner bodies would be better at dissipating excess body heat, as it creates the best body surface area to volume ratio. 温度升高也会影响我们的体型变化。更高、更瘦的身材会更好地散发多余的身体热量，正因为它是最佳的身体表面积与体积比。英语百科 Body surface area In physiology and medicine, the body surface area (BSA) is the measured or calculated surface area of a human body. For many clinical purposes BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the use of BSA in determining the dosage of medications with a narrow therapeutic index, such as chemotherapy. Typically there is a 4–10 fold variation in drug clearance between individuals due to differing the activity of drug elimination processes related to genetic and environmental factors. This can lead to significant overdosing and even more perniciously to underdosing (and increased risk of disease recurrence). It is also thought to be a distorting factor in Phase I and II trials that may result in potentially helpful medications being prematurely rejected. The trend to personalized medicine is one approach to counter this weakness. Estimation of BSA is simpler than many measures of volume.
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