This is one of the major points in the difference between fasting and caloric restriction.

这就是断食和卡路里限制最主要的一个不同点。

This is why you'll experience more muscle loss on caloric restriction than if you ate nothing.

这就是为什么限制卡路里摄入会比禁食减少更多能量的原因。

Those findings suggest that caloric restriction could delay aging and increase longevity in humans, too.

这一发现意味着限制卡路里摄入可以延缓衰老并且延长人类寿命。

By limiting food intake, caloric restriction minimizes the amount of glucose entering cells and decreases ATP generation.

通过限制食物摄入，卡路里限制作用使进入细胞的葡萄糖数量降至最低从而减少 ATP 的生成。

But it has demonstrated that chemicals can replicate the effects of caloric restriction; the trick is finding the right one.

但是我们确信，可以通过药物来产生卡路里限制的效应，问题就在于哪种药物比较合适。

The benefits of caloric restriction The hunt for CR mimetics grew out of a desire to better understand caloric restriction's many effects on the body.

卡路里限制的好处寻找卡路里限制替代品的动机，源于人们想要更好的理解卡路里限制为人体带来的诸多效应。

However, it does illustrate some very interesting points about just how different of a physiological response you get from fasting (that is, eating nothing) compared to eating less, or caloric restriction.

然而，这的确向我们展示了一些有趣的事实，那就是绝食（什么都不吃）带来的生理反应与少食或限制卡路里摄入相比有哪些不同。

As an October 2011 study in the New England Journal of Medicine says: " Caloric restriction results in acute compensatory changes, including profound reductions in energy expenditure and levels of leptin and cholecystokinin and increases in ghrelin and appetite."

正如 2011 年 10 月发表在《新英格兰医学杂志》上的一项研究所说：“热量限制会导致急性代偿性变化，包括能量消耗、瘦素和胆囊收缩素水平的显著降低，以及胃饥饿素和食欲的增加。”

Scientists first posed this question in the mid-1990s, after researchers came upon a chemical agent that in rodents seemed to reproduce many of caloric restriction's benefits.

科学家最初提出这个问题是在 20 世纪 90 年代中期，那时他们刚刚发现了一种化学制剂，它在啮齿类动物体内似乎能够产生很多卡路里限制效应。

For example, many people have had weight loss success on caloric restriction diets; but some will find later on that it's difficult to maintain the lost weight thanks to an adaptation called " metabolic adaptation" .

例如，很多人通过限制热量摄入的办法成功地减轻了体重；但部分人后来发现，由于“代谢适应“现象，他们很难保持理想体重。