Casamassima is a town and comune in the province of Bari, in Apulia, southern Italy.

The town is located inland from the Italian coastline, thrives and is built on agriculture, primarily that of wine, olives and almond production.

Casamassima can be found in the Bari Province of the Apulian region in the Southern Zone of Italy. Only 223 metres (732 ft) above sea level from the Adriatic Sea, and consisting of a population of approximately 16,388 (equating to about 211.7 people per square kilometer), this township is located on one of the eastern terraces of the Murge. The Murge is a characteristic area of Apulia that is composed of limestone hills, near the edge of the Bari basin (conca di Bari—A depression formed when the underlying limestone is eroded by underground water and collapses).