Cassino ['kas'sino] is a comune in the province of Frosinone, Italy, at the southern end of the region of Lazio.

Cassino is located at the foot of Monte Cairo near the confluence of the Gari and Liri rivers. The city is best known as the site of the Abbey of Montecassino and the Battle of Monte Cassino during World War II, which resulted in huge Allied and German casualties as well as the near total destruction of the town itself. Today, Cassino is also home to the University of Cassino and a Fiat-Chrysler automotive plant.