硫族化物或硫属化物（chalcogenide）是指至少含有一个硫族元素（氧族元素中除了氧以外的元素）离子及一个电负性较小元素的化合物。一般硫族元素是指硫、硒、碲、钋及Lv等元素，而电负性较小元素一般是指砷、锗、磷、锑、锑、铅、硼、铝、镓、镓、铟、钛、钠等元素。

静电复印术及电视中都有用到具有光电导性的硫族化物玻璃。

雪梨大学开发了用硫族化物作为光侦测器的光学处理芯片，可能可以提升光纤网络和电脑之间的传输速度。

许多以离子键键结的硫族化物（例如硫化铁或硫化镉）存在含硫的矿石中，也常作为颜料使用，例如朱砂（硫化汞）、镉黄（硫化镉）、镉红（硒化镉）及可用作白色颜料的硫化锌。

A chalcogenide is a chemical compound consisting of at least one chalcogen anion and at least one more electropositive element. Although all group 16 elements of the periodic table are defined as chalcogens, the term chalcogenide is more commonly reserved for sulfides, selenides, and tellurides, rather than oxides. Many metal ores exist as chalcogenides. Photoconductive chalcogenide glasses are used in xerography. Some pigments and catalysts are also based on chalcogenides. The metal dichalcogenide MoS₂ is a common solid lubricant.