Copiapó (Spanish pronunciation: [kopjaˈpo]) is a city in northern Chile, located about 65 kilometers east of the coastal town of Caldera. Founded on December 8, 1744, it is the capital of Copiapó Province and Atacama Region.

Copiapó lies about 800 km north of Santiago by the Copiapó River, in the valley of the same name. In recent years, the river has dried up. The town is surrounded by the Atacama Desert and receives 12 mm (½ in) of rain per year. The population of Copiapó was 9,128 in 1903, 11,617 in 1907 and, as of 2012, there are 158,438 inhabitants.