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单词 Aldehyde reductase
释义

Aldehyde reductase

中文百科

醛糖还原酶 Aldose reductase

（重定向自Aldehyde reductase）
多元醇通路
Mechanism of NADPH-dependent conversion of glucose to sorbitol. Note the hydride transfer from NADPH to the carbonyl carbon of the aldose.
Depiction of NADPH in extended confirmation and hydrogen bonded to the residues physically near the active site of the enzyme.

醛糖还原酶（aldose reductase，AR，EC1.1.1.21）存在于人体神经、红细胞、晶状体、视网膜等组织器官中，在多元醇通路中催化血液中的葡萄糖生成山梨醇。

英语百科

Aldose reductase 醛糖还原酶

（重定向自Aldehyde reductase）
Mechanism of NADPH-dependent conversion of glucose to sorbitol. Note the hydride transfer from NADPH to the carbonyl carbon of the aldose.
Depiction of NADPH in extended confirmation and hydrogen bonded to the residues physically near the active site of the enzyme.
Role of aldehyde reductase (shown in yellow box) in norepinephrine degradation, contributing in the creation of MHPG, a minor catecholamine metabolite.[6]

In enzymology, aldose reductase (or aldehyde reductase) (EC1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism.
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更新时间：2025/6/21 3:41:52