Osteitis fibrosa cystica

X-ray of a pair of human tibia, which run from the top right and left corner of the image into the bottom center, where they almost converge. Small gray blemishes, identified as brown tumors, can be seen at the top and halfway down the right tibia and about three-quarters down the length of the left tibia.

Diagram showing position of the parathyroid glands beside the thyroid

X-ray of the hands showing brown tumors in the long bones of the fingers

Histology of bone showing osteitis fibrosa cystica. (Fibrosis and intratrabecular tunnels are seen).

Osteitis fibrosa cystica /ˌɒstiːˈaɪtᵻs faɪˈbroʊsə ˈsɪstᵻkə/, abbreviated OFC, also known as osteitis fibrosa, osteodystrophia fibrosa, and Von Recklinghausen's disease of bone (not to be confused with Von Recklinghausen's disease, neurofibromatosis type I), is a skeletal disorder caused by hyperparathyroidism, which is a surplus of parathyroid hormone from over-active parathyroid glands. This surplus stimulates the activity of osteoclasts, cells that break down bone, in a process known as osteoclastic bone resorption. The hyperparathyroidism can be triggered by a parathyroid adenoma, hereditary factors, parathyroid carcinoma, or renal osteodystrophy. Osteoclastic bone resorption releases minerals, including calcium, from the bone into the bloodstream. In addition to elevated blood calcium levels, over-activity of this process results in a loss of bone mass, a weakening of the bones as their calcified supporting structures are replaced with fibrous tissue (peritrabecular fibrosis), and the formation of cyst-like brown tumors in and around the bone. The symptoms of the disease are the consequences of both the general softening of the bones and the excess calcium in the blood, and include bone fractures, kidney stones, nausea, moth-eaten appearance in the bones, appetite loss, and weight loss.

单词	Osteitis fibrosa cystica
释义	Osteitis fibrosa cystica 英语百科 Osteitis fibrosa cystica Osteitis fibrosa cystica /ˌɒstiːˈaɪtᵻs faɪˈbroʊsə ˈsɪstᵻkə/, abbreviated OFC, also known as osteitis fibrosa, osteodystrophia fibrosa, and Von Recklinghausen's disease of bone (not to be confused with Von Recklinghausen's disease, neurofibromatosis type I), is a skeletal disorder caused by hyperparathyroidism, which is a surplus of parathyroid hormone from over-active parathyroid glands. This surplus stimulates the activity of osteoclasts, cells that break down bone, in a process known as osteoclastic bone resorption. The hyperparathyroidism can be triggered by a parathyroid adenoma, hereditary factors, parathyroid carcinoma, or renal osteodystrophy. Osteoclastic bone resorption releases minerals, including calcium, from the bone into the bloodstream. In addition to elevated blood calcium levels, over-activity of this process results in a loss of bone mass, a weakening of the bones as their calcified supporting structures are replaced with fibrous tissue (peritrabecular fibrosis), and the formation of cyst-like brown tumors in and around the bone. The symptoms of the disease are the consequences of both the general softening of the bones and the excess calcium in the blood, and include bone fractures, kidney stones, nausea, moth-eaten appearance in the bones, appetite loss, and weight loss.
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